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Given to healthy adults, the levels of IgG to toxin A were higher than levels associated with protection in other studies. Active immunization with this vaccine was used in combination with antibiotics to successfully treat three patients with RCDI (131). There is no convincing evidence for efficacy of bile salt binders or whole gut lavage (132,133,134).
There has been a significant increase in the incidence of CDI in IBD patients, with recurrence in up to one-third in both children and adults (144,145,146,147,148).