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This way, the variance component for age should be interpreted as that not already explained by ACG. These models were estimated using the restricted maximum likelihood method. In a first step, a binary logistic regression using ACG as a covariate was applied to predict the incurrence of drug expenditure.
Nagelkerke R 2 was used to estimate the proportion of variance explained. We chose this measure knowing its limitations as an approximation to the coefficient of determination in a linear model.