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Finally, the use of probiotics is not regulated by the Food and Drug Administration, there is no good quality control for most probiotics, and studies have shown that some probiotics contain no live organisms, or alternatively, contain organisms not on the product label (118,119).
In view of the lack of efficacy data, abundant data on potential harm, high costs, and lack of biological plausibility for these non-human micro-organisms to confer colonization resistance, their use cannot be recommended.
Two patients with RCDI were given a non-toxigenic strain of C. Intravenous immune globulin (IVIG) does not have a role as sole therapy in treatment of RCDI; however, it may be helpful in patients with hypogammaglobulinemia.
(Strong recommendation, low quality of evidence).